My company truck is up to 360,000 now. I put 39,000 on it this year and the quarter mod under one of the UVCH's has been my only hiccup this year engine wise. The truck had a new bedside put on it, tires, rear leaf springs, front end work, brakes, serpentine belt and basic maintenance. So we put about f $4k into this year and I feel its poised to go another 100,000 miles with a good cost per dollar number attached to it.
Some would say heck with that, putting $4K into a truck that old is a waste but I will stand by it. I believe the 7.3 PSD is about as good as it gets for going the distance economically.