Not usually but you MUST watch very closely to all lines under the cab when tilting forward or back. After its loaded just clean out the cab (put everything in the storage box if it has one) and/or secure all loose objects in the cab for obvious reasons. Under the cab riser undo the 4 or so smaller bolts at the front and 6 or 8 big bolts at the back. Its nice to have a guy watching in the cab riser through the door as you tilt it down. If wiring repairs, coolant line repairs, etc have been done sometimes if the cab it not tilted often they may have shortcutted and the lines may be too short when the cab lays down.
More often then not the problems happen when tilting the cab back up - coolant and a/c lines love to get pinched at the front of the riser. Also last year I slightly damaged the cab tilt cylinder on a 345C when tilting it back cause the big cab support cable and turnbuckle caught the oil line on the cylinder and pinched it slightly (I wasn't watching close enough). Also on that machine there was a 12" x 12" or so electrical box installed on the rear of the riser that had to be unbolted (4 M8 bolts) and left laying down as the cab was tilted. Depending on what attachments are installed (grapple, power clam, butt-n-top, etc and who did the install) a couple of things may have to be removed but if it was done right and clean it should be straight forward with very few if any things to remove.
Just have to be careful and watch all lines carefully when tilting. Also when the cab is laying down it usually is right over the trailer tires so have some wood or cardboard to protect the front window from rocks