4045 HF285 2012 - a few months ago, I had to pull a used engine that was not running correctly. Fresh rebuild from the evidence. They had the fuel injection pump timing off by one tooth.
I scored a brand new fuel injection pump with pump mounted sensors from Ebay for about $400. 4 new injectors at $220 ea, all new sensors for the rail pressures, relief valves, etc. All of these parts were sourced from Ebay at big discounts. I changed out everything while the engine was out and I could access the parts.
After the engine was re-installed, runs perfect with no problems. Never had any computers hooked up to reset injectors or anything else. This is also a Tier 3 engine with no EGR but it does have a particulate exhaust filter with European DEF system (Satacen 3 Fluid).
From what my JD dealer told me, the computer will fine tune the injectors to meet emissions with the injector tuning code programmed in. Without the code, the engine will run fine but may or may not meet emissions standards if the injectors are changed out or swapped in cylinder locations.