The 500 ton class will be broken someday. I don't see it being done as Lunaticfreak suggests though. The more weight you take away, the more pay load you can carry, yes, this is true. But most of the weight will no be able to be removed, and if you start cutting material from some components and structures, you will inevitably weaken them. With the conditions these trucks face all day long, that would add up to failure of components or structures alarmingly fast.
If anything, I see there being a break for a while and then a slow build up to a larger size tire, then truck. It may even take a different wheel/axle configuration to get there, but with modern technology, that may not have the same issues that past designs had with tandem trucks, or other setups.
Now 1000 tonners, yeah, I think that may be a bit out there.
Brian